RecruitingNot ApplicableNCT05644327

Exercise to Improve Sleep in Parkinson's Disease

The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease

Sponsor

McGill University

Enrollment

150 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.

Eligibility

Min Age: 40 Years

Inclusion Criteria3

Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5);
On a stable dosage of medication during the previous month;
Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;

Exclusion Criteria8

Having atypical parkinsonism, dementia, stroke, or any other neurological condition;
Presenting severe untreated obstructive sleep apnea (OSA);
Having a Montreal Cognitive Assessment (MoCA) score \<18
Having a Beck Depression Inventory score \>31;
Having absolute contraindications to exercise;
Having severe osteoporosis;
Participating in an exercise or drug trial during the period of the study;
Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.