In-patient SCC TMS

This study is testing an intensive form of brain stimulation called accelerated TMS (transcranial magnetic stimulation) for people who are hospitalized with severe, treatment-resistant depression that has not responded to multiple antidepressants or other therapies. **You may be eligible if...** - You are between 18 and 65 years old - You have moderate to severe major depressive disorder (a HAM-D score of 17 or higher) - You have tried and not responded to at least 2 different antidepressant medications from at least 2 different drug classes - You have also tried at least two augmentation strategies and an adequate course of psychotherapy - You are currently hospitalized and able to follow an intensive treatment schedule **You may NOT be eligible if...** - You have a metal implant in or near your head (e.g., aneurysm clip) or another contraindication to TMS - You have a history of seizures, bipolar disorder, or a psychotic disorder - You are unable to give informed consent - You have an active infection or other serious medical condition Talk to your doctor to see if this trial is right for you.