RecruitingPhase 3NCT05648812

Neonatal Brain Ultrasound With CEUS and Elastography

Contrast Enhanced Ultrasound and Elastography of the Neonatal Brain


Sponsor

Turku University Hospital

Enrollment

100 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. We use contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography to evaluate the state of brain perfusion. We will study neonates recruited from the Neonatal Units of Turku University Hospital.


Eligibility

Min Age: 1 MinuteMax Age: 6 Months

Plain Language Summary

Simplified for easier understanding

This study uses special ultrasound techniques — contrast-enhanced ultrasound (CEUS) and elastography — to examine the brains of newborns and very young babies being treated in neonatal units. These techniques may be able to detect brain problems earlier or more accurately than standard ultrasound. The study is observational, meaning researchers are just imaging and observing, not giving experimental treatments. You may be eligible if: - Your baby is under 7 months old - Your baby is receiving care in the neonatal unit at Turku University Hospital You may NOT be eligible if: - Your baby has a known genetic disease - Your baby has a complex birth defect requiring surgery - Your baby has a brain tumor - Your baby weighs less than 2.5 kg at the time of examination - Your baby has a known allergy to SonoVue (the ultrasound contrast agent) - Your baby has uncontrolled high blood pressure or heart instability Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTBrain contrast enhanced ultrasound, brain ultrasound elastography

To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography

DRUGSulfur Hexafluoride

To evaluate the differences in brain perfusion studied by CEUS, comparing different patient groups and babies with no suspected brain pathology


Locations(1)

Turku University Hospital

Turku, Southwestern Finland, Finland

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NCT05648812


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