RecruitingPhase 4NCT05649059

Investigating the Effects of Cannabidiol on Social Anxiety Disorder


Sponsor

Massachusetts Institute of Technology

Enrollment

50 participants

Start Date

Jul 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder (SAD).


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether CBD (cannabidiol), a non-psychoactive compound from cannabis, can reduce symptoms of social anxiety disorder. Participants will take CBD or a placebo and undergo brain imaging (fMRI) while doing tasks that trigger social stress. **You may be eligible if...** - You are between 18 and 55 years old and right-handed - You have been diagnosed with social anxiety disorder - Your current medications have been stable for at least 30 days **You may NOT be eligible if...** - You have other significant psychiatric conditions - You use cannabis or CBD regularly - You have contraindications to MRI (e.g., metal implants) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCannabidiol

Participants randomized to the cannabidiol arm will receive 3mL of Epidiolex (100mg cannabidiol/mL) in a single-dose.

DRUGPlacebo

Participants randomized to the placebo arm will receive 3mL of placebo (sesame seed oil) in a single dose.


Locations(1)

Massachusetts Institute of Technology

Cambridge, Massachusetts, United States

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NCT05649059