RecruitingNCT05653063

ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer

Sponsor

University College, London

Enrollment

990 participants

Start Date

Dec 7, 2023

Study Type

OBSERVATIONAL

Conditions

Cancer of Prostate Cancer Head Neck Cancer Cervix

Summary

The aim of this study is to look at whether an Artificial Intelligence (AI) based computer program can automate two components of the radiotherapy treatment pathway to a sufficient quality standard to enable its routine clinical use. The two components include the delineation (outlining) of anatomical areas that are at risk of tumour spread and at risk of radiation damage, and the definition of the position, size and shape of the radiation beams. The AI-based computer programs have been developed to perform tasks that would normally require direct human involvement by oncologists and medical physicists. Proposed advantages include improved treatment accuracy, as well as a reduction in the time (from weeks to minutes) and human resources needed to deliver radiotherapy, which this study will test.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether AI-generated radiation therapy treatment plans — for head and neck, cervical, and prostate cancers — are as good as or better than plans made by expert human radiation oncologists. It aims to make high-quality radiation planning more accessible. **You may be eligible if...** - You have been diagnosed with head and neck cancer (oropharynx, larynx, hypopharynx, or nasopharynx, Stage I–III), cervical cancer (Stage IB–IIIB), or prostate cancer - You have consented to receive radical (curative) radiotherapy - Your diagnosis has been confirmed by biopsy **You may NOT be eligible if...** - You are not a candidate for curative radiation therapy - Your cancer is at a stage outside the study criteria - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERA web-based artificial intelligence (AI) auto-planning tool

The CT scan taken at the time of treatment planning is uploaded to a web server called the Radiotherapy planning assistant which automates the contouring of target organs and areas of high-risk disease as well as defining the size, shape and number of radiotherapy beams to treat the cancer. The final plan is downloaded to the local treatment planning system where the doses are recalculated and clinical peer review is undertaken before the plan can be used clinically. In this study patients will not be treated with the AI tool but the manual plan created by the local teams.