A Feasibility and Safety Study of Intratumoral Diffusing Alpha Radiation Emitters for the Treatment of Advanced Pancreatic Cancer

This study tests a new type of targeted radiation called Alpha DaRT — tiny radioactive seeds inserted directly into a tumor — for people with advanced pancreatic cancer that has spread or cannot be surgically removed and has not responded to chemotherapy. **You may be eligible if...** - You have confirmed advanced or metastatic pancreatic cancer - You have already tried at least one chemotherapy regimen, or are medically unable to receive further chemotherapy - Your tumor cannot be surgically removed, or you have chosen not to have surgery - Your tumor is 5 cm or smaller and can be targeted by the seeds - You are 18 or older with an ECOG health status of 0–2 - Your life expectancy is more than 6 months **You may NOT be eligible if...** - You have never tried chemotherapy and are still eligible for it - Your tumor is too large or not technically accessible for seed placement - Your blood counts, organ function, or overall health do not meet minimum requirements Talk to your doctor to see if this trial is right for you.