A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

This study tests whether adding targeted radiation to liver tumors improves how well immunotherapy (checkpoint inhibitor drugs) and chemotherapy work in people with stage IV non-small cell lung cancer (NSCLC) that has spread to the liver. **You may be eligible if...** - You are over 18 years old - You have been confirmed to have stage IV non-small cell lung cancer (either newly metastatic or progressed from stage III) - Your cancer does not have EGFR, BRAF, ALK, or ROS1 mutations - You have one or more liver metastases - You are about to start standard immunotherapy (anti-PD-L1 based) with or without chemotherapy - Your general health is adequate **You may NOT be eligible if...** - Your lung cancer has driver mutations (EGFR, ALK, BRAF, or ROS1) - You do not have liver metastases - You are not a candidate for standard immunotherapy - Your overall health is too poor for treatment Talk to your doctor to see if this trial is right for you.