Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

This study looks at how well saline (saltwater) nasal rinses help people recover after surgery to remove a pituitary tumor through the nose. Researchers want to find out if rinsing with saline improves nasal comfort and outcomes after this type of surgery. **You may be eligible if...** - You are an adult (18–85 years old) having endoscopic surgery through the nose to remove a pituitary tumor (including non-functioning adenoma, acromegaly, prolactinoma, or Rathke's cleft cyst) - You speak English and can complete standard nasal symptom questionnaires - The surgery is planned through both nostrils **You may NOT be eligible if...** - You have an active sinus infection, allergic rhinitis, or asthma - You have a history of previous sinus or nasal surgery - You have nasal polyps, chronic sinusitis, or a history of radiation to the skull base - You have an immune deficiency - You are pregnant or incarcerated - You are currently taking antibiotics for an unrelated condition - You have Cushing's disease Talk to your doctor to see if this trial is right for you.