RecruitingNCT05669183

Hemodynamic Comparison of Peripheral and Central VA ECMO.

Comparison of Peripheral and Central Intubation on Hemodynamics in Veno-arterial-extracorporeal Membrane Oxygenation (RECOVERY): a National, Multi-center, Prospective, Cohort Study

Sponsor

First Affiliated Hospital Xi'an Jiaotong University

Enrollment

136 participants

Start Date

Aug 12, 2023

Study Type

OBSERVATIONAL

Conditions

Cardiac Arrest Hemodynamics Instability Shock, Cardiogenic Extracorporeal Circulation; Complications

Summary

The goal of this clinical trial is to monitor hemodynamic differences between central veno-arterial extracorporeal membrane oxygenation (VA ECMO) and peripheral VA ECMO. The main question it aims to answer is: * Efficacy of the different cannulation strategies for the establishment of for VA-ECMO circulation on hemodynamics and organ perfusion. Participants require VA ECMO support, will be divided into two groups in an intention-to-treat analysis: central artery cannulation and peripheral artery cannulation. Researchers will analyze different cannulation strategies for VA-ECMO and identify potential advantages and disadvantages for two groups of VA-ECMO.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age≥18 years
Participants with cardiogenic shock
Obtaining informed consent from participants or their affiliated beneficiaries

Exclusion Criteria5

Irreversible heart failure
Contraindications to anticoagulation therapy
Uncontrolled bleeding
Irreversible neurological pathology
Participants limited to extracorporeal cardiopulmonary resuscitation

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Interventions

PROCEDUREVeno-arterial extracorporeal membrane oxygenation

Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is mainly used for circulatory support in patients with severe cardiopulmonary failure. VA ECMO drains the blood from the venous system followed pumping the blood back into the arterial vascular compartment after oxygenation. It can be divided into two cannulation strategies for VA ECMO support, namely peripheral VA ECMO and central VA ECMO based on the arterial cannulation site. Peripheral VA ECMO is established via the femoral artery (FA), whereas axillary artery (AX) is an arterial cannulation site in central VA-ECMO.