RecruitingNCT05671198

Sonographic Diaphragm Function in AECOPD

Ultrasound of the Diaphragm As Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Sponsor

Isala

Enrollment

51 participants

Start Date

Mar 27, 2023

Study Type

OBSERVATIONAL

Conditions

COPD

Summary

The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Hospitalisation primarily because of severe acute exacerbation of COPD
COPD, according to GOLD 2018 definition
Post-bronchodilator FEV1/FVC \< 0,70 and FEV1% \< 80%pred. within last 5 years

Exclusion Criteria6

Respiratory acidosis (pH \< 7.35 ánd PaCO2 \> 6 kPA)
Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.
Established diagnosis of diaphragm diaphragm paralysis.
Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).
Those not able or unwilling to give written informed consent.
Pregnant women

Interventions

DIAGNOSTIC_TESTUltrasound of the diaphragm

Sonographic parameters of the diaphragm: * Thickening Fraction (TF); (Diaphragm thickness end-inspiration- Diaphragm thickness end-expiration) / Diaphragm thickness end-expiration. (continuous variable). * Diaphragm end-expiratory thickness: Diaphragm thickness at end-expiration (continuous variable) * Diaphragm excursion (DE): diaphragm inspiratory amplitude during deep breathing (continuous variable).