RecruitingNot ApplicableNCT05674331

Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Alveolar Ridge Preservation

Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Hard- and Soft- Tissue Changes Following Alveolar Ridge Preservation


Sponsor

Semmelweis University

Enrollment

63 participants

Start Date

Sep 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

With alveolar ridge preservation (ARP) ridge resorption following extraction may be reduced. Several materials and techniques have been advocated for ARP. The aim of our randomised clinical trial is to evaluate the efficacy of extraction side development technique (XSD) and autogenous tooth bone graft (ATB) for ARP.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a technique called alveolar ridge preservation (ARP) — a procedure done at the time of tooth extraction to maintain the shape and volume of the jawbone so it can support a dental implant later. The study compares different ARP approaches using clinical measurements, X-rays, tissue analysis, and blood flow data to determine which technique best preserves bone after tooth removal. **You may be eligible if...** - You are 18 or older - You have good individual oral hygiene (FMBS below 25%) - You are in treatment or under treatment for periodontal disease with minimal active inflammation (FMPS below 25%) - You have a tooth that needs to be extracted due to advanced periodontal or endo-periodontal disease, which will be replaced with a dental implant **You may NOT be eligible if...** - You have an active infectious disease (HIV, hepatitis B or C, COVID-19, etc.) - You are currently receiving chemotherapy or radiation therapy - You have had radiation to the head or neck in the past 2 years - You have untreated insulin-dependent diabetes - You have significant osteoporosis or bone-affecting systemic disease - You have severe heart disease, decompensated heart failure, or had a heart attack in the past 3 months - You have significant clotting disorders - You are on corticosteroids (in the past 2 months) or bisphosphonates (more than 30 days) - You are pregnant or breastfeeding - You smoke more than 5 cigarettes per day - You have a drug or alcohol addiction **Talk to your periodontist or oral surgeon if** you need a tooth extracted and are planning to get a dental implant, and want to learn about bone-preserving techniques that can improve implant success.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREExtraction site development technique

The technique is described by Molnar et al. in 2019. The aim is to reconstruct the buccal bony wall with a xenogenic membrane with a slow absorption rate properties. This technique aims to stabilizate and enlarge the blood clot .

DEVICEautogenous tooth bone graft

ATB was invented by Kim et al. in 2011. The extracted tooth is grinded and goes throw a sterilization procedure by the manufacturer's recommendation. The graft material can be used immediately for ARP.

PROCEDURESocket seal technique

After tooth removal neither graft nor any membrane material is inserted to the extraction socket. A soft tissue pounch is harvested from the hard palate and it is fixed above the extraction socket with single interrupted sutures.


Locations(1)

Semmelweis University Department of Periodontology

Budapest, Hungary

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NCT05674331


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