3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

This study compares two stereotactic body radiation therapy (SBRT) schedules — 3 treatments versus 5 treatments — for palliating (relieving symptoms from) head and neck squamous cell carcinoma in patients who are no longer eligible for curative treatment. SBRT delivers very precise, high-dose radiation in fewer sessions than standard radiation. **You may be eligible if...** - You are 18 or older - You have confirmed squamous cell carcinoma of the head or neck (mouth, throat, voice box, or nearby areas) - You have been determined to be ineligible for curative treatment after a multidisciplinary evaluation - You have had prior treatment (radiation, surgery, or systemic therapy) **You may NOT be eligible if...** - You are still eligible for curative-intent treatment - You have not been evaluated by both a radiation oncologist and surgeon - Your tumor site is not in the defined head and neck region - You are unwilling to provide informed consent Talk to your doctor to see if this trial is right for you.