RecruitingPhase 1NCT06444815

A Study of VET3-TGI in Patients With Solid Tumors

A Phase 1/1b Study of VET3-TGI Administered Alone and in Combination With Atezolizumab in Patients With Advanced Solid Tumors


Sponsor

KaliVir Immunotherapeutics

Enrollment

60 participants

Start Date

Sep 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

VET3-TGI is an oncolytic immunotherapy designed to treat advanced cancers. VET3-TGI has not been given to human patients yet, and the current study is designed to find a safe and effective dose of VET3-TGI when administered by direct injection into tumor(s) (called an intratumoral injection) or when given intravenously (into the vein) both alone and in combination with atezolizumab in patients with solid tumors (STEALTH-001).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an experimental drug called VET3-TGI, given directly into tumors (intra-tumoral injection), in patients with advanced solid cancers. The drug is designed to stimulate the immune system to attack cancer cells. The trial focuses on safety and how the immune system responds. **You may be eligible if...** - You have an advanced, inoperable, or metastatic solid tumor (including breast, bladder, cervical, colorectal, ovarian, sarcoma, and others) - You have already tried or been unable to tolerate standard treatments - Your cancer is measurable on scans - You have at least one tumor accessible for injection - You are in good general health (ECOG 0 or 1) **You may NOT be eligible if...** - You have active brain metastases or cancer spread to the lining of the brain - You have a history of myocarditis (inflammation of the heart muscle) - You have HIV, active hepatitis B or C - You are on high-dose immune-suppressing medications - You need blood thinners that cannot be safely paused for biopsies Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVET3-TGI

Oncolytic vaccinia virus engineered with immunomodulatory transgenes

DRUGAtezolizumab

anti-pd-L1 antibody


Locations(7)

USC/Norris Comprehensive Cancer Center

Los Angeles, California, United States

UC Irvine Health

Orange, California, United States

University of Miami

Miami, Florida, United States

Community Health Network

Indianapolis, Indiana, United States

UPMC- Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

Mary Crowley Cancer Research

Dallas, Texas, United States

University of Texas MD Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06444815


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