RecruitingPhase 2Phase 3NCT05674552

Exogenous Ketone Esters for Refractory Status Epileptics

Efficacy of Exogenous Ketone Esters for Children With Refractory Convulsive Status Epileptics

Sponsor

Sohag University

Enrollment

50 participants

Start Date

Jan 10, 2023

Study Type

INTERVENTIONAL

Conditions

Status Epilepticus

Summary

This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus

Eligibility

Min Age: 1 YearMax Age: 10 Years

Inclusion Criteria1

Refractory Generalized convulsive status epilepticus.

Exclusion Criteria14

Failure to obtain informed consent.
Recent intake of exogenous ketones, ketogenic diet, or any dietary restrictions/modifications.
Hemodynamic or cardio-respiratory instability.
Traumatic brain injury.
Hypo-/hyperglycemia.
Metabolic acidosis.
Ketosis (βHB > 2 mmol/L).
Associated severe disease condition, including hepatic, renal, respiratory, cardiac, gastrointestinal, endocrinal, and immune systems.
Malnutrition/obesity.
Limitations to nasogastric tube feeding.
Inborn errors of metabolism.
Allergies or any other contraindication to exogenous ketone esters.
Current or recent (within the last 24 hours) propofol therapy.
Intake of carbonic-anhydrase inhibitors.