RecruitingPhase 2NCT05675787

Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia

Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Atypical Endometrial Hyperplasia and Early Endometrial Carcinoma


Sponsor

Peking University People's Hospital

Enrollment

82 participants

Start Date

Jan 6, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To explore the treatment efficacy of medroxyprogesterone acetate plus atorvastatin in patients with atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC) for conservative treatment.


Eligibility

Sex: FEMALEMin Age: 17 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding a cholesterol-lowering drug (atorvastatin) to a standard hormonal therapy (medroxyprogesterone acetate) can improve outcomes for young women with early-stage uterine cancer or abnormal uterine cell growth, while preserving their ability to have children. **You may be eligible if...** - You are a young woman diagnosed with early uterine lining cancer (Grade 1) or atypical uterine cell growth confirmed by biopsy - There is no sign the cancer has spread outside the uterus on imaging - You want to preserve your uterus or your ability to have children **You may NOT be eligible if...** - You are pregnant or may be pregnant - You have been diagnosed with another gynecologic cancer - You already take cholesterol-lowering medications - You have serious liver, kidney, or blood clotting problems - You have had a stroke, heart attack, or history of blood clots - You smoke heavily (more than 15 cigarettes per day) or drink heavily (more than 20g alcohol per day) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMedroxyprogesterone acetate + Atorvastatin

MPA (at a dosage of 250-500 mg/day,) + Atorvastatin (at a dosage of 20 mg/day), by mouth,


Locations(1)

Wang Jianliu

Beijing, Beijing Municipality, China

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NCT05675787


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