Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

This study is testing a combination of two treatments for locally advanced pancreatic cancer — a precise form of radiation called SBRT combined with a wearable electric field device (Tumor Treating Fields) — for patients whose cancer has not spread but cannot be surgically removed. **You may be eligible if...** - You have been confirmed to have locally advanced pancreatic cancer (adenocarcinoma) - You have received at least 3 months of chemotherapy (FOLFIRINOX or gemcitabine/nab-paclitaxel) without your cancer spreading further - Your cancer marker (CA 19-9) is not extremely elevated - You are in good enough health (ECOG 0–1) and your organ function is adequate - You are able to wear and operate the electric field device independently or with help **You may NOT be eligible if...** - Your cancer has spread to other parts of the body - You have had prior abdominal radiation - You have inflammatory bowel disease (Crohn's or colitis) - You have a pacemaker or other electrical implant in your torso - You are pregnant or breastfeeding - You are allergic to the adhesive pads used with the electric field device Talk to your doctor to see if this trial is right for you.