Tissue Destruction and Healing in Celiac Disease

This study investigates how the intestinal lining breaks down and heals in people with celiac disease when they are exposed to or removed from gluten. It compares celiac patients with healthy people. You may be eligible if you: - Are aged 18 to 75 - Have a confirmed celiac disease diagnosis (if in gluten challenge/de-challenge groups) or are a healthy control - Have followed a strict gluten-free diet for at least 12 months (challenge group) or have not been on a gluten-free diet and have typical symptoms (de-challenge group) You may NOT be eligible if you: - Have severe complications of celiac disease - Have other chronic active gastrointestinal diseases - Have selective IgA deficiency - Are pregnant or lactating - Have blood clotting disorders - Are a healthy control with a family history of celiac disease or prior GI surgery Talk to your doctor to see if this trial is right for you.