Treatment of Chronic Hand Eczema With Oral Roflumilast (HERO)

This study (HERO) tests whether roflumilast, an oral medication, can reduce inflammation and improve chronic hand eczema — a skin condition causing persistent, uncomfortable redness and rash on the hands. You may be eligible if you: - Are aged 18 to 75 - Have moderate to severe chronic hand eczema (HECSI ≥18, IGA-CHE ≥3) - Have a BMI of at least 20 kg/m² - Are willing to use contraception during the study (if applicable) - Read and understand Danish You may NOT be eligible if you: - Have a severe immune disease (HIV, lupus, systemic sclerosis) - Have active tuberculosis or viral hepatitis - Have or have had depression with suicidal thoughts - Are currently pregnant or breastfeeding - Are allergic to roflumilast Talk to your doctor to see if this trial is right for you.