Usefulness of PET-CT for Invasive Fungal Infection
A Prospective Multicenter Study to Determine the Usefulness of Systematic 18-FDG-PET-TC for the Management of Invasive Fungal Infection (PETIFI Project)
Puerta de Hierro University Hospital
224 participants
Apr 27, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this national multicenter prospective cohort study is to learn about the added value of 18F-FDG (18F-2-fluoro-2-deoxy-D-glucose) PET-CT in invasive fungal disease management. The main questions it aims to answer are: 1. Does the use of 18F-FDG PET-CT allow a better characterization of invasive fungal infection (IFI) (performance) compared to the exclusive use of conventional radiological studies in terms of extension/staging and monitoring of response/follow-up ? 2. Does the systematic and protocolized use of 18F-FDG PET-CT in IFI allow a better management of patients with IFI and increase the prognostic value of the initial evaluation? Participants will undergo systematically a 18F-FDG PET-CT as part of the work-up of their invasive fungal disease. Researchers will compare the performance of 18F-FDG PET-CT with standard management without 18F-FDG PET-CT to see if adds value (diagnostic, prognostic, and changes in management).
Eligibility
Inclusion Criteria4
- -year-old adult patients
- who are admitted with a diagnosis of invasive fungal infection
- who able to undergo a one 18F-FDG PET-CT
- who give their informed consent.
Exclusion Criteria4
- concomitant active bacterial infection likely to produce uptake in organs and tissues
- recent surgery in the area of the IFI (in the previous 3 months)
- other medical conditions that interfere with the development of the study ( e.g., inability to tolerate the performance of the test during the required time, pregnancy)
- terminal situation.
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Interventions
This is a before-and-after study (not a clinical trial) * in the case of fungemia, 2 weeks after the initial staging 18F-FDG PET-CT. * in the case of focal IFIs, 2-4 and 12 weeks after the initial staging 18F-FDG PET-CT
Locations(14)
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NCT05688592