COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

This study (COMMENCE) investigates whether drinking coffee and its metabolites changes the gut bacteria in colorectal cancer survivors — and whether those changes might reduce the risk of cancer coming back. **You may be eligible if...** - You are 18 or older - You have been diagnosed with stage I, II, or III colon or rectal cancer confirmed by biopsy - You have completed your standard cancer treatment (surgery, chemotherapy, and/or radiation) at least 2 months ago - You are willing to follow study procedures and agree to use contraception if applicable **You may NOT be eligible if...** - You are currently receiving any other cancer treatment or enrolled in another interventional study - You are pregnant or trying to become pregnant - You have conditions that would make it unsafe to consume coffee in the amounts required by the study Talk to your doctor to see if this trial is right for you.