RecruitingNCT05692726
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial (EvenT)
Sponsor
University of Cologne
Enrollment
50 participants
Start Date
Oct 15, 2022
Study Type
OBSERVATIONAL
Conditions
Summary
To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Adult patients ≥ 18 years
- Hypotonic hyponatremia
- glucose-corrected plasma sodium <130 mmol/l
- serum osmolality <280 mosmol/kg or lack of signs of non-hypotonic hyponatremia
Exclusion Criteria5
- Signs of extracellular volume expansion
- Patients with liver cirrhosis and severe liver damage AST/ALT>3xULN, AP>6xULN, Bilirubin ≥ 3mg/dl
- Patients with heart failure
- Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl
- Patients after organ transplantation
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Interventions
OTHERPatients
Patients will get study-specific measurements within first 5 days of standard of care treatment of hyponatremia or until discharge
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05692726