Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes

This study tests a combination of add-on therapies designed to address multiple metabolic problems in people with type 1 diabetes — including insulin resistance, kidney issues, and cardiovascular risk — beyond what standard insulin treatment alone can do. **You may be eligible if...** - You are 18–70 years old with type 1 diabetes based on a clinical or lab diagnosis - You have been on a stable insulin regimen for at least 8 weeks - Women must either be post-menopausal, surgically sterile, or using two forms of contraception; men must agree to use contraception during the study **You may NOT be eligible if...** - You have severe kidney, liver, or heart problems - You have unstable blood sugar control or frequent severe low blood sugar episodes - You are pregnant, breastfeeding, or planning to become pregnant during the study - You have recently changed your diabetes medications Talk to your doctor to see if this trial is right for you.