Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

This study tests a new approach to treating chronic joint pain in the shoulder, hip, or knee using a minimally invasive procedure called joint embolization — blocking some of the abnormal new blood vessels that grow in painful arthritic joints and are thought to contribute to pain and inflammation. The procedure is guided by a special MRI technique that maps blood flow in and around the joint. You may be eligible if: - You are a US Veteran receiving care through the VA system - You are between 25 and 80 years old - You have had chronic pain in your shoulder, hip, or knee for at least 1 year - You have mild to moderate degenerative joint changes confirmed by imaging - You have tried at least one treatment for your pain (such as physical therapy, NSAIDs, or steroid injections) without adequate relief - A clinical provider has ordered an MRI of your painful joint You may NOT be eligible if: - You had an acute joint injury in the last 12 weeks - You have severe degenerative changes in the joint - You have had a joint replacement or metal implant in the affected joint - You have severe renal disease or are on dialysis - You are currently pregnant - You have a severe allergy to gadolinium or iodinated contrast agents - You have a history of malignancy with life expectancy under one year Talk to your doctor to see if this trial is right for you.