RecruitingPhase 2NCT05709782

Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC


Sponsor

M.D. Anderson Cancer Center

Enrollment

40 participants

Start Date

May 9, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests the use of a specialized radiation machine called an MR-Linac to deliver precise stereotactic radiotherapy (SRS/SBRT) to cancer that has spread to the spine. Unlike standard radiotherapy, MR-Linac combines real-time MRI imaging with radiation delivery, allowing doctors to precisely target spinal tumors while avoiding the spinal cord. This precision may improve tumor control and reduce the risk of nerve damage. You may be eligible if: - You are 18 or older and have cancer that has spread to the spine (confirmed on imaging within 4 weeks) - You have up to 3 consecutive vertebral levels involved with cancer - A radiation oncologist or spine team has determined you are a candidate for spine SRS/SBRT - You have adequate muscle strength in limbs affected by your spine disease (grade 4 out of 5 or better) - Your performance status is Karnofsky 40 or better (or ECOG 3 or less) You may NOT be eligible if: - Your cancer type is highly radiation-sensitive (e.g., lymphoma, multiple myeloma) and likely responds to conventional radiation - You cannot undergo an MRI with contrast of the spine - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESpine Radiosurgery

scan

DEVICEMagnetic Resonance imaging

scan

RADIATIONMR-LINAC

scan


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT05709782


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