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RecruitingPhase 2NCT05709782

Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Sponsor

M.D. Anderson Cancer Center

Enrollment

40 participants

Start Date

May 9, 2023

Study Type

INTERVENTIONAL

Conditions

Spinal Disease

Summary

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.

Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • Age ≥ 18 years old
  • Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
  • Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
  • Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
  • Diagnosis of cancer documented
  • Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
  • Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3

Exclusion Criteria3

  • Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
  • Patients who are unable to undergo MRI of the spine with contrast
  • Patients who are pregnant

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Interventions

PROCEDURESpine Radiosurgery

scan

DEVICEMagnetic Resonance imaging

scan

RADIATIONMR-LINAC

scan

Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT05709782

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