RecruitingPhase 2NCT05709782
Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC
Sponsor
M.D. Anderson Cancer Center
Enrollment
40 participants
Start Date
May 9, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.
Eligibility
Min Age: 18 Years
Inclusion Criteria7
- Age ≥ 18 years old
- Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
- Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
- Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
- Diagnosis of cancer documented
- Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
- Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3
Exclusion Criteria3
- Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
- Patients who are unable to undergo MRI of the spine with contrast
- Patients who are pregnant
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Interventions
PROCEDURESpine Radiosurgery
scan
DEVICEMagnetic Resonance imaging
scan
RADIATIONMR-LINAC
scan
Locations(1)
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NCT05709782