Cost-utility of Focal HIFU vs Prostatectomy

This study is comparing two treatments for low-risk localized prostate cancer: focal HIFU (high-intensity focused ultrasound, which destroys only the cancerous part of the prostate) versus radical prostatectomy (complete surgical removal of the prostate), looking at which is more cost-effective and what quality of life each provides. **You may be eligible if...** - You are a man aged 45–75 with localized prostate cancer (not spread beyond the gland) - Your cancer is low-to-intermediate risk (Gleason score no higher than 3+4, on only one side) - Your PSA level is below 20 ng/mL and prostate volume is under 150 mL - Your cancer is visible on MRI and confirmed by biopsy - You are affiliated with a social security scheme **You may NOT be eligible if...** - Your cancer has spread beyond the prostate (metastatic) - Your Gleason score is higher than 3+4 (more aggressive cancer) - You have a specific aggressive cancer subtype (cribriform or intraductal) - You have had prior cancer treatment - You cannot have an MRI with contrast dye or cannot undergo anesthesia - You have certain urinary implants or anatomical issues that prevent HIFU Talk to your doctor to see if this trial is right for you.