Bleeding of Unknown Cause: a Swiss Case-control Study
Bleeding of Unknown Cause, Insight Into a Multifactorial Bleeding Disorder: a Swiss Case-control Study
University Hospital, Geneva
400 participants
Apr 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.
Eligibility
Inclusion Criteria2
- Man with ISTH BAT>3. If the calculated score includes a surgical bleeding, then two other items of the score should be >0
- Woman with ISTH BAT >5 points. If the calculated score includes a surgical or a postpartum bleeding, then two other items of the score should be >0
Exclusion Criteria12
- Ongoing pregnancy
- Intake of antithrombotic treatment or non-steroidal anti-inflammatory drugs for least 10 days at time of blood collection
- Intake of antifibrinolytic or blood product administration (factor concentrate, frozen fresh plasma, prothrombin complex concentrate) for least 14 days before blood collection
- Active cancer (defined as cancer diagnosis within the last five years or treatment within the two last years before study inclusion)
- Active autoimmune disease
- Active chronic inflammatory disease
- Severe liver disease (cirrhosis > Child A)
- Renal insufficiency stage 3
- Active or recent infection (within the last 30 days)
- Recent hospitalization (<3 months)
- Recent surgery (<3 months)
- Recent trauma requiring medical intervention (<3 months)
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Interventions
Measurement of thrombin generation by ST Genesia
Measurement of fibrinolysis by Lysis Timer
Measurement of fibrin polymerisation and permeability
Measurement of coated platelets by flow cytometry
Locations(7)
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NCT05713734