Laparoscopic Versus Open Right Colectomy for Right Colon Cancer
Comparison of Laparoscopic Versus Open Right Colectomy for Right Colon Cancer, According to the Complete Mesocolic Excision (CME) Principles: a Prospective Randomized Controlled Trial
Larissa University Hospital
114 participants
Feb 6, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of this research protocol is to compare open versus laparoscopic right colectomy (according to the CME technique of complete mesocolic excision) for right colon cancer. This study will be designed as a prospective randomized controlled trial. The comparison of the two techniques will include endpoints regarding the quality characteristics of the specimens and the oncological results. In addition, the effectiveness of the two methods will be evaluated in terms of the early and late postoperative period.
Eligibility
Inclusion Criteria7
- Histologically confirmed right colon cancer (cecum, ascending colon, hepatic flexure)
- Surgical resection based on the CME principles
- Patient 18 to 90 years old
- American Society of Anesthesiologists score ≤III
- Τ≤3
- Elective operation
- Signed informed consent of the patient
Exclusion Criteria11
- Non elective operation (hemorrhage, perforation, obstruction)
- Locally advanced disease (T4)
- Distant metastases (Stage IV)
- American Society of Anesthesiologists ≥IV
- Previous laparotomy
- BMI \>35 kg/m2
- Active sepsis or systemic infection
- Untreated physical and mental disability
- Pregnancy or breast-feeding
- Lack of compliance with the protocol process
- Non-granting of signed informed consent
Interventions
Resection of the ascending colon via a laparoscopic approach, adhering to the CME principles
Resection of the ascending colon via an open approach, adhering to the CME principles
Locations(1)
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NCT05713903