RecruitingNCT05718440

Uronephrological Complications Risk Factors in Spinal Dysraphism

Individualisation of Uronephrological Complications Risk Factors in Spinal Dysraphism


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

200 participants

Start Date

Nov 6, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Spinal dysraphism consist of congenital malformations resulting of abnormalities in the formation of neural tube and/or surrounding structures during embryogenesis. The aim of this study is to assess if there are specific clinical and paraclinical patterns of pelvic (urinary, bowel, sexual) disorders depending on the dysraphism's type and level of injury. This description will help to determine a prognosis on symptoms and the risk of complication depending on the dysraphism's type and level of injury. It will provide targeted evaluation and cares: identifying patients who will be at risk of complications and needing acute monitoring or preventing cares on the symptoms' onset. Pelvic disorders have an important impact on morbi-mortality (urinary dysfunction is the first cause of mortality in adults by renal failure or infection) and also on patients' quality of life.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • men and women over 18 years old with spinal dysraphism,
  • urinary and/or bowel and/or sexual dysfunction,
  • evaluated in a one day consultation in a neuro-urology department.
  • Informed consent is required from the patient or his tutor/curator if he is under legal protection

Exclusion Criteria2

  • language barrier with non-understanding of French language,
  • other neurologic pathologies except syringomyelia, Chiari malformation or hydrocephalus who are often associated to spinal dysraphism.

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Interventions

OTHERIndividualisation of uronephrological complications risk factors

description of pelvic disorders in terms of clinical presentation, electrophysiology/urodynamics/anorectal manometry patterns, urethrocystography/urinary ultrasound/defecography results and urinary complications (infections, vesicoureteral reflux), depending on the dysraphim's type and level of injury and to correlate these parameters to the uronephrological risk factors and complications recorded.


Locations(1)

Tenon hospital

Paris, France

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NCT05718440


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