Functional Pulmonary Capillary Surface Area in BPA for CTEPH
Assessment of Recovery of Functional Capillary Surface Area in Patients Undergoing a Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Jewish General Hospital
40 participants
Mar 23, 2023
INTERVENTIONAL
Conditions
Summary
Chronic thromboembolic pulmonary hypertension \[CTEPH\] is caused by pulmonary emboli that have enlarged in pulmonary arteries and have become organized into the vessel wall. Many patients with CTEPH are treated with balloon pulmonary angioplasty \[BPA\] which mechanically opens the narrow pulmonary arteries. It is unclear how much downstream functional pulmonary capillary surface area \[FCSA\] is recovered during BPA. The investigators plan to measure FCSAIn CTEPH patients, before and after a session of BPA.
Eligibility
Inclusion Criteria1
- All patients eligible for balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
Exclusion Criteria2
- Treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers,
- Presence of patent foramen ovale
Interventions
Measurement of transpulmonary metabolism of trace injected doses of benzoyl-Phe-Ala-Pro
Locations(1)
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NCT05719415