RecruitingNot ApplicableNCT05719415

Functional Pulmonary Capillary Surface Area in BPA for CTEPH

Assessment of Recovery of Functional Capillary Surface Area in Patients Undergoing a Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension


Sponsor

Jewish General Hospital

Enrollment

40 participants

Start Date

Mar 23, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Chronic thromboembolic pulmonary hypertension \[CTEPH\] is caused by pulmonary emboli that have enlarged in pulmonary arteries and have become organized into the vessel wall. Many patients with CTEPH are treated with balloon pulmonary angioplasty \[BPA\] which mechanically opens the narrow pulmonary arteries. It is unclear how much downstream functional pulmonary capillary surface area \[FCSA\] is recovered during BPA. The investigators plan to measure FCSAIn CTEPH patients, before and after a session of BPA.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring how the blood vessels in the lungs respond and recover after a procedure called balloon pulmonary angioplasty (BPA) — a treatment for chronic thromboembolic pulmonary hypertension (CTEPH), a condition where old blood clots narrow the lung's blood vessels and raise blood pressure in the lungs. Specifically, researchers will use an imaging technique to measure pulmonary capillary surface area before and after treatment. **You may be eligible if...** - You have chronic thromboembolic pulmonary hypertension (CTEPH) and have been approved to undergo balloon pulmonary angioplasty **You may NOT be eligible if...** - You are taking ACE inhibitors or angiotensin receptor blockers (ARBs), a common class of blood pressure medications - You have a patent foramen ovale (a small hole between the upper chambers of the heart that failed to close after birth) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMeasurement of pulmonary functional capillary surface area

Measurement of transpulmonary metabolism of trace injected doses of benzoyl-Phe-Ala-Pro


Locations(1)

David Langleben

Montreal, Quebec, Canada

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NCT05719415


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