Novel Setup Algorithm for Cardiac Neuromodulation Therapy

This study is testing a new automatic programming method for a dual-chamber pacemaker that also provides a special heart nerve stimulation therapy (cardiac neuromodulation) to lower blood pressure in patients who have both a pacemaker indication and uncontrolled high blood pressure. **You may be eligible if...** - You are 18 or older and need a new or replacement dual-chamber pacemaker (or an upgrade from single to dual chamber) - You have high blood pressure (office systolic BP between 140-180 mmHg) on 1-3 blood pressure medications, which have been stable for at least 1 month - Your heart's pumping function is 50% or better **You may NOT be eligible if...** - Your high blood pressure is caused by a known secondary condition (e.g., thyroid disease, adrenal tumor) - You have permanent or frequent atrial fibrillation - You have significant heart failure symptoms (NYHA class II or above) - You have had a stroke or TIA in the past year, or a heart attack or heart procedure in the past 3-6 months Talk to your doctor to see if this trial is right for you.