EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

This study is testing a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) — where a probe is inserted through an endoscope to deliver heat energy directly into a pancreatic tumor — for patients with locally advanced pancreatic ductal adenocarcinoma (PDAC, the most common type of pancreatic cancer) that cannot be surgically removed and has not responded to first-line chemotherapy. **You may be eligible if...** - You have confirmed pancreatic cancer (PDAC) that is locally advanced but has not spread to distant organs - Your tumor is between 1 and 4 cm in size and accessible by endoscope - Your cancer did not respond or progressed on first-line chemotherapy - Your general health is reasonable (ECOG 0-2) **You may NOT be eligible if...** - Your cancer has spread to distant parts of the body (metastatic) - The tumor cannot be reached safely by endoscope - You are pregnant - Your tumor is smaller than 1 cm or larger than 4 cm Talk to your doctor to see if this trial is right for you.