RecruitingNot ApplicableNCT05724641

Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application


Sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Enrollment

70 participants

Start Date

Jan 10, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a specialized MRI technique called Arterial Spin Labeling (ASL) to measure blood flow within the human eye, specifically in patients with optic neuropathies (diseases affecting the optic nerve). The goal is to validate this non-invasive imaging method as a reliable way to assess eye perfusion, which could improve how these conditions are diagnosed and monitored. You may be eligible if: - You are 18 years or older - You have one of the target optic neuropathies: thyroid eye disease optic neuropathy, inflammatory optic neuropathy, or ischemic optic neuropathy - You do not have cardiovascular risk factors or other eye diseases - You have no contraindications to MRI - You agree to follow the study protocol and sign informed consent You may NOT be eligible if: - You have a contraindication to MRI (such as a pacemaker, metal implants, or cochlear implant) - You have severe claustrophobia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMRI perfusion imaging using ASL's non-invasive technique

Patients will undergo through an MRI-scan using the ASL MRI sequence, as described per protocol.


Locations(1)

Cliniques Universitaires Saint Luc

Brussels, Brussels Capital, Belgium

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NCT05724641


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