RecruitingPhase 4NCT05726136

Fluid Challenge and Plasma Volume, During Surgery

Comparison of Albumin and Ringer's Solution for Optimization of the Plasma Volume and Hemodynamics During Laparoscopic Surgery.

Sponsor

Joachim Zdolsek

Enrollment

60 participants

Start Date

Oct 23, 2023

Study Type

INTERVENTIONAL

Conditions

Colorectal, Cancer Gynecologic Cancer Urologic Cancer Colorectal Disorders Benign Neoplasm

Summary

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how fluids given during surgery affect blood volume in the body. By giving a carefully measured fluid challenge during laparoscopic abdominal surgery, researchers aim to better understand how to manage fluids safely during operations. **You may be eligible if...** - You are 18–80 years old - You are scheduled for laparoscopic abdominal surgery lasting at least 90 minutes - Your overall health is classified as ASA I to III - If you are a woman of childbearing age, you have a reliable form of contraception or a negative pregnancy test **You may NOT be eligible if...** - You have known kidney disease or fluid balance disorders - You are pregnant - You have conditions that affect how your body handles fluids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGacetated Ringers

After insufflation of carbon dioxide during an abdominal laparoscopic procedure, the first fluid bolus is infused. Circulatory and volume effects are studied. If cardiac output increase a second bolus is infused and studied.

DRUGalbumin 5%

After insufflation of carbon dioxide during an abdominal laparoscopic procedure, the first bolus of fluid is infused. Circulatory and volume effects are studied. If cardiac output increases a second bolus is infused and studied.

DRUGalbumin 20%

Locations(1)

Vrinnevi Hospital

Norrköping, Östergötland County, Sweden

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NCT05726136

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