RecruitingNot ApplicableNCT05734261

Forced Oscillations Technique During a Metacholine Test in Children

Interest of Forced Oscillations During a Methacholine Test in Children


Sponsor

University Hospital, Montpellier

Enrollment

112 participants

Start Date

Sep 7, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Asthma is the most common chronic lung disease in children. It affects more than 1 in 10 children in France. The methacholine bronchial challenge test (MBT) is indicated to assess the probability of asthma suggested by clinical symptoms by measuring the forced expiratory volume in one second (FEV1), after inhalation of a cumulative dose of methacholine. In children, the measurement of FEV1 requires a high level of cooperation from the child, which can be the source of false negatives or no result if this is not obtained. The objective of this study is to evaluate if the measurement of the respiratory function by the forced oscillations technique, allows to predict the variation of the FEV1 obtained


Eligibility

Min Age: 6 YearsMax Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study uses a breathing measurement technique called forced oscillations technique (FOT) during a standard asthma-provocation test (methacholine challenge) in children. The methacholine test checks how reactive the airways are, and FOT offers a non-invasive way to detect early airway changes. The goal is to see whether FOT can provide additional useful information about lung function in children, potentially improving asthma diagnosis. **You may be eligible if...** - Your child is between 6 and 16 years old - They have lung function above 60% predicted (FEV1 > 60%) - They have been referred for a methacholine bronchial reactivity test - They have been off inhaled corticosteroids for at least 3 weeks - The child and at least one parent/guardian have given oral consent **You may NOT be eligible if...** - Your child has used a short-acting inhaler (reliever) in the last 6 hours, or a long-acting inhaler in the past 36 hours - They have had a respiratory tract infection in the last 3 weeks - They have epilepsy under active treatment - They are enrolled in another study that could affect breathing test results Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAirway Oscillation System

After each methacholine dose administred, respiratory function will be measured by forced oscillation


Locations(1)

CHU de Montpellier

Montpellier, France

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NCT05734261


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