RecruitingNot ApplicableNCT05737732

The Ambient Light Multiple Myeloma Study

Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation


Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

200 participants

Start Date

Feb 13, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. To achieve this aim, 200 multiple myeloma patients will receive one of two different light-treatments that are designed to promote circadian rhythm alignment. While receiving these light treatments, participants' sleep efficiency, urine melatonin levels, blood inflammatory cytokine levels and symptoms will be assessed over a 2-month period.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether using a special type of light therapy during recovery can help multiple myeloma patients who are about to receive their first stem cell transplant — a common treatment for this blood cancer. The goal is to improve sleep and overall well-being during the difficult transplant period. **You may be eligible if...** - You have been diagnosed with multiple myeloma - You are 21 years old or older - You are scheduled to undergo your first autologous stem cell transplant (using your own stem cells) - You are able to speak and understand English **You may NOT be eligible if...** - You have had a stem cell transplant before - You are pregnant - You have an eye condition that prevents light from being processed normally - You have been diagnosed with another cancer in the past 5 years - You have severe sleep disorders, a history of bipolar disorder or manic episodes, or severe psychological problems - You have an active infection, including COVID-19 - You have previously used light therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICECircadian Effective Lighting

Participants will receive lighting with a spectrum of 300K, 500 lux to the eye level between 7:00am and 10:00am in the morning, and hospital lighting (\<100lux) during the afternoon between 10:00am and 6:00pm. In the evening this group of participants will receive lighting with a spectrum of 3000K, \<50lux at eye light level between 6:00PM and bedtime.

DEVICECircadian Ineffective Lightning (CIL)

Participants will receive lower lighting levels in the morning (lighting with A spectrum of 300k, \<50lux to the eye level between 7:00am and 10:00am) and the same lighting levels throughout the rest of the day.


Locations(2)

Icahn Schoool of Medicine at Mount Sinai

New York, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05737732


Related Trials