RecruitingNCT05740683
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Sponsor
Danish Dementia Research Centre
Enrollment
100 participants
Start Date
Feb 1, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
Eligibility
Min Age: 55 YearsMax Age: 75 Years
Inclusion Criteria6
- Age 55 -75 years of age
- Slowly progressing and non-fluctuating iOD
- Able to give informed consent and to cooperate as evaluated by the PI
- Age 55 -75 years of age
- Able to give informed consent
- Able to cooperate as evaluated by the PI
Exclusion Criteria13
- Diagnosed with a neurodegenerative disease or major neurological/psychiatric condition.
- Anosmia/hyposmia caused by sino-nasal disease (including chronic rhinitis and allergy), after trauma, infection, congenial, olfactory dysfunction due to surgery, or toxins/drugs affecting the olfactory function.
- Olfactory dysfunction with response to systemic or local corticosteroids if tried
- Severe nasal cavity abnormalities or infections.
- Overt signs of dementia or PD
- Current alcohol or drug abuse
- Terminal illness
- Diagnosed with neurodegenerative disease or major neurological/psychiatric condition.
- Olfactory dysfunction on clinical test
- Overt signs of dementia or PD
- Severe nasal cavity abnormalities or infections.
- Current alcohol or drug abuse
- Diagnosed with neurodegenerative disease or major neurological/psychiatric condition.
Interventions
DIAGNOSTIC_TESTRT-QuiC
RT-QuIC measures the ability of aSyn to misfold other aSyn proteins and is an amplification technique.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05740683