RecruitingNCT05745961

Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)


Sponsor

Imperial College London

Enrollment

6 participants

Start Date

Feb 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The aim of this study is to determine whether there is an increase in the TSPO PET signal (measured with the radioligand \[11C\]PBR28) in the lungs of patients living with PAH relative to age matched controls. If so, TSPO PET may be a useful technique to non-invasively monitor response to therapy. To do this, we will perform 2 \[11C\]PBR28 PET scans. The first will quantify the total \[11C\]PBR28 PET signal. This signal is a combination of the specific signal (VS) and the nonspecific signal (VND). The second scan will be performed following dosing with an unlabelled TSPO ligand. By directly measuring the total \[11C\]PBR28 signal (scan 1) and the nonspecific \[11C\]PBR28 signal (scan 2) we can therefore calculate the specific \[11C\]PBR28 signal, and hence the amount of TSPO in the lung.


Eligibility

Min Age: 25 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is using a special type of brain/body scan (called a PET scan with a radioactive tracer) to measure a specific protein in the lungs of people with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is abnormally high. Researchers hope this will help better understand and diagnose PAH. **You may be eligible if...** - You have pulmonary arterial hypertension (PAH) - You are able to lie still on your back for up to 90 minutes - You can provide written informed consent in English - Women of childbearing age must use effective contraception and have a negative pregnancy test **You may NOT be eligible if...** - You have a specific genetic variant (TT genotype at rs6971) that affects the scan tracer - You have significant kidney or liver disease - You have severe anemia, sickle cell disease, or thalassemia - You have uncontrolled high blood pressure - You have a current infection, HIV, or chronic inflammatory disease including hepatitis B - You are pregnant or breastfeeding - You have participated in another drug study recently Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONTSPO PET scan (11C-PBR28)

PET scan


Locations(1)

Imperial Clinical Research Facility

London, United Kingdom

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NCT05745961


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