RecruitingPhase 2NCT05753826

Adebrelimab Combined With Fuzuloparib in the Treatment of Patients With Recurrent Platinum-resistant Ovarian Cancer.

A Single-arm, Exploratory Study of Adebrelimab Combined With Fuzuloparib in the Treatment of Patients With Recurrent Platinum-resistant Ovarian Cancer


Sponsor

Fujian Cancer Hospital

Enrollment

37 participants

Start Date

Aug 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, exploratory study. People with recurrent platinum-resistant ovarian cancer who have not received any previous systemic antitumor therapy for ovarian cancer were selected to evaluate the efficacy and safety of adebrelimab combined with fuzuloparib.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two drugs — adebrelimab (an immunotherapy) and fuzuloparib (a PARP inhibitor that targets DNA repair) — in women with ovarian cancer that has come back within 6 months after platinum-based chemotherapy, a situation called platinum-resistant recurrence. **You may be eligible if...** - You are a woman between 18 and 70 years old - You have been diagnosed with epithelial ovarian, fallopian tube, or primary peritoneal cancer - Your cancer returned within 6 months after your last platinum chemotherapy - Your tumor has a mutation in HRR genes (genes involved in DNA repair), confirmed by a tissue or blood test - You have at least one measurable tumor on imaging - Your performance status is ECOG 0–1 **You may NOT be eligible if...** - Your cancer did not return within 6 months of platinum treatment - You do not have an HRR gene mutation - You have already had more than a certain number of prior treatment lines Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAdebrelimab

20mg/kg,D1,q3W

DRUGFuzuloparib

100 mg bid


Locations(1)

Fujian Cancer Hospital

Fujian, China

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NCT05753826


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