Imlifidase Prior to Kidney Transplant in Highly Sensitised Children

This study is testing imlifidase, an enzyme that temporarily removes certain antibodies from the blood, in highly sensitized children waiting for a kidney transplant. This could make it possible for these children to receive a transplant from donors they previously could not accept due to immune incompatibility. **You may be eligible if...** - You (or your child) are between 1 and 17 years old - You have end-stage kidney disease and are waiting for a kidney transplant - You have very high levels of antibodies (panel reactive antibodies ≥80%) that make it hard to find a compatible donor - A parent or guardian (and the patient, where age-appropriate) has given informed consent **You may NOT be eligible if...** - You (or your child) are 18 or older - Antibody levels are not high enough to qualify - You do not have end-stage renal disease requiring a transplant Talk to your doctor to see if this trial is right for you.