Quadruple Immunotherapy for Neuroblastoma
Quadruple Immunotherapy for Paediatric Patients With Relapsed or Refractory Neuroblastoma
Hong Kong Children's Hospital
29 participants
Jan 1, 2022
INTERVENTIONAL
Conditions
Summary
This is a single-arm clinical trial to evaluate the efficacy and safety of quadruple immunotherapy with natural killer (NK) cells, anti-GD2 antibody, cytokines (interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF)) and retinoid X receptor gamma (RXRg) agonist spironolactone for paediatric patients with relapsed or refractory neuroblastoma.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Natural killer cells isolated from HLA-haploidentical relative donor
Dinutuximab beta iv for 5 days
Interleukin-2 sc alternate day for 6 doses
Granulocyte-macrophage colony-stimulating factor sc daily till ANC \>2,000/mm3
Spironolactone po three time daily
Naxitamab iv for 4 days (as alternative for dinutuximab)
Locations(1)
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NCT05754684