Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

This study is evaluating a new medical device called the Nephronyx System in people who are hospitalized with acute decompensated heart failure (ADHF) — a condition where the heart suddenly becomes unable to pump blood properly, causing dangerous fluid buildup — and whose kidneys are not responding well to diuretic (water pill) medications. **You may be eligible if...** - You are admitted to hospital primarily because of severe heart failure - You have visible signs of excess fluid in your body - Your heart pumping function is above 15% - Your kidneys are not responding adequately to diuretics (water pills) - Your blood marker for heart stress (NT-proBNP or BNP) is elevated **You may NOT be eligible if...** - You have a blood clot in your leg veins (DVT) or history of DVT - You have a narrowing of the arteries supplying your kidneys - Your BMI is above 35 - You have untreated abnormal heart rhythms or recent heart procedures - You have severe kidney disease requiring dialysis Talk to your doctor to see if this trial is right for you.