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RecruitingEarly Phase 1NCT05761860

The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

Sponsor

University of Florida

Enrollment

45 participants

Start Date

Sep 12, 2023

Study Type

INTERVENTIONAL

Conditions

Pain

Summary

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.

Eligibility

Min Age: 45 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called OxyCODONE 2.5 mg Oral Tablet, a drug called OxyCODONE 5 mg Oral Tablet, and others for people with pain. The study is currently recruiting participants at 1 location. People eligible for this study include aged 45 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOxyCODONE 5 mg Oral Tablet

Oxycodone 5mg oral administration

DRUGOxyCODONE 2.5 mg Oral Tablet

Oxycodone 2.5mg oral administration

OTHERPlacebo oxyCODONE Oral Tablet

Oxycodone 0mg (placebo) oral administration

DRUGOxytocin Nasal Spray (48 IU)

Intranasal oxytocin administration (48 IU)

OTHERPlacebo Oxytocin Nasal Spray

Intranasal oxytocin placebo administration

Locations(1)

University of Florida

Gainesville, Florida, United States

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NCT05761860

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