Pain Clinical Trials

2,623 recruitingLast updated: June 17, 2026

There are 2,623 actively recruiting pain clinical trials across 85 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1, Early Phase 1. Top locations include Boston, Massachusetts, United States, Istanbul, Turkey (Türkiye), New York, New York, United States. Updated daily from ClinicalTrials.gov.


Pain Trials at a Glance

2,623 actively recruiting trials for pain are listed on ClinicalTrialsFinder across 6 cities in 85 countries. The largest study group is Not Applicable with 1,574 trials, with the heaviest enrollment activity in Boston, Istanbul, and New York. Lead sponsors running pain studies include Riphah International University, Cairo University, and Beijing Tiantan Hospital.

Treatments under study

About Pain Clinical Trials

Looking for clinical trials for Pain? There are currently 432 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 2,623 trials

Recruiting

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

Chronic Low-back PainVertebrogenic Pain Syndrome
Boston Scientific Corporation1,500 enrolled18 locationsNCT06827262
Recruiting

Emotional Intelligence and Chronic Orofacial Pain

Chronic Pain
University Hospital, Brest88 enrolled1 locationNCT07280338
Recruiting
Not Applicable

Comparison of the Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block

Pain, PostoperativeThoracic Surgery, Video-assistedMultimodal Analgesia+2 more
Ankara City Hospital Bilkent90 enrolled1 locationNCT07650877
Recruiting
Phase 1

Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults

Neuropathic Pain
Alcamena Stem Cell Therapeutics72 enrolled1 locationNCT07363395
Recruiting
Phase 4

PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain

Trigger Point in Trapezius MuscleMyofascial Pain Dysfunction SyndromeTrigger Points, Myofascial
University of Kyrenia150 enrolled2 locationsNCT07547605
Recruiting

Effect of Bilateral Ultrasound-Guided TAP Block on Quality of Recovery in Cesarean Delivery Patients Receiving Intrathecal Morphine

Postoperative Pain ManagementObstetric AnesthesiaRecovery From Anesthesia
MEHMET GÖKHAN TAFLAN150 enrolled1 locationNCT07145619
Recruiting
Phase 4

Comparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy

Postoperative Pain
Wah Medical college , POF hospital106 enrolled1 locationNCT07650760
Recruiting
Phase 4

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Opioid UsePostoperative PainAnesthesia+5 more
University of Crete40 enrolled1 locationNCT04894864
Recruiting

MRI Study of Musculoskeletal Function

Patellofemoral Pain SyndromeAbnormalitiesImaging
National Institutes of Health Clinical Center (CC)750 enrolled1 locationNCT00051857
Recruiting

Isokinetic Profile of Ankle Joint Muscles in Chronic Non Specific Low Back Pain Patients

Chronic non-specific low back pain
Cairo University50 enrolled1 locationNCT07636967
Recruiting
Not Applicable

Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

PainDepressionAnxiety+2 more
Boston Medical Center80 enrolled1 locationNCT06812247
Recruiting
Not Applicable

Chronic Unilateral Lumbar Radicular Pain

Neuropathic Pain
Ain Shams University80 enrolled1 locationNCT06092749
Recruiting
Not Applicable

Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors

Postoperative PainLiver TransplantationLiving Donor
Istinye University64 enrolled1 locationNCT07233096
Recruiting
Not Applicable

Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia

Postoperative Pain
Ain Shams University120 enrolled1 locationNCT06818396
Recruiting
Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Post Operative PainChronic PainKnee Pain Chronic
University Health Network, Toronto400 enrolled3 locationsNCT06123715
Recruiting
Phase 3

Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children

Chronic PainNeuropathic Pain
University Hospital, Brest46 enrolled10 locationsNCT05997979
Recruiting
Not Applicable

Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy

Postoperative PainHysterectomyPlane Blocks
Istinye University60 enrolled1 locationNCT07483190
Recruiting
Phase 3

Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

Diabetic peripheral neuropathic pain
Vertex Pharmaceuticals Incorporated1,100 enrolled76 locationsNCT06628908
Recruiting
Not Applicable

Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery

SurgeryPain ManagementPatient-controlled Analgesia+1 more
Beijing Tiantan Hospital1,170 enrolled1 locationNCT07361822
Recruiting

Registry of Outcomes of Dezawa MuseCells®

longevityOsteoarthritis (OA)Pain+2 more
MuseCell Innovations Pte LTD5,000 enrolled2 locationsNCT07645989