Pain Clinical Trials

395 recruiting

Pain Trials at a Glance

2,152 actively recruiting trials for pain are listed on ClinicalTrialsFinder across 6 cities in 83 countries. The largest study group is Not Applicable with 1,248 trials, with the heaviest enrollment activity in Boston, Istanbul, and New York. Lead sponsors running pain studies include Riphah International University, Cairo University, and Beijing Tiantan Hospital.

Treatments under study

About Pain Clinical Trials

Looking for clinical trials for Pain? There are currently 395 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 2,152 trials

Recruiting

Clinical and Scientific Assessment of Pain and Painful Disorders

PainNormal Physiology
National Center for Complementary and Integrative Health (NCCIH)10,000 enrolled1 locationNCT02707029
Recruiting
Not Applicable

Music Use in Parturients Admitted to Labor & Delivery

PainPatient SatisfactionAnxiety
Tufts Medical Center106 enrolled1 locationNCT06969105
Recruiting
Not Applicable

Brain Circuitry Changes in Central Poststroke Pain: a Clinical and Neuroimaging Study

PainCPP
Insel Gruppe AG, University Hospital Bern88 enrolled1 locationNCT05335668
Recruiting
Phase 1

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Palliative CareIntractable Pain
National Institute of Dental and Craniofacial Research (NIDCR)45 enrolled1 locationNCT00804154
Recruiting
Phase 4

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

Pain, PostoperativeSpine FusionLumbar Spine Degeneration+1 more
University of Southern California140 enrolled1 locationNCT05746143
Recruiting

The Impact of Gender Affirming Hormone Therapy on Pain In Gender Minority Adults

PainGender Minority Individuals
University of Kansas Medical Center200 enrolled1 locationNCT06939257
Recruiting

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

Chronic Low-back PainVertebrogenic Pain Syndrome
Boston Scientific Corporation1,500 enrolled16 locationsNCT06827262
Recruiting
Not Applicable

Telerehabilitation-based Exercises vs Standard Home-based Exercise in Low Back Pain

Low Back Pain
University of Valencia30 enrolled1 locationNCT06446596
Recruiting
Phase 1Phase 2

Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study

Diabetic NeuropathiesDiabetic Peripheral Neuropathic Pain (DPN)
Florida A&M University20 enrolled1 locationNCT07298408
Recruiting
Not Applicable

A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

PainTemporomandibular Joint Disorders
University of Alcala60 enrolled3 locationsNCT05272488
Recruiting
Not Applicable

Dry Needling and Patients Treatment Expectations

Neck Pain; Dry Needling; Motivation
University of Alcala45 enrolled1 locationNCT04636879
Recruiting
Phase 3

Management of Moderate to Severe Monotraumatic Pain With Sublingual Sufentanil in an Emergency Situation.

Pain Management
University Hospital, Clermont-Ferrand300 enrolled1 locationNCT06917651
Recruiting
Not Applicable

Effects of Dry Needling on the Behavior of the Shoulder Muscles

Shoulder Pain
University of Alcala40 enrolled1 locationNCT06398574
Recruiting
Not Applicable

Therapeutic Cuddling in Critically Ill Children

PainDelirium in the Intensive Care Unit
University of Calgary112 enrolled1 locationNCT07562048
Recruiting
Early Phase 1

A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes

Pain, AcuteBurns
University of Manitoba30 enrolled1 locationNCT03695887
Recruiting
Not Applicable

Comparison of the Analgesic Effects of TFPB in Renal Transplantation Surgery

Pain ManagementRenal TransplantationPeripheral Nerve Block
Ankara Etlik City Hospital50 enrolled1 locationNCT07542028
Recruiting
Not Applicable

Virtual Reality Therapy for Cancer-Treatment Associated Symptoms

CancerCancer PainVirtual Reality
University of Maryland, Baltimore30 enrolled2 locationsNCT06248216
Recruiting
Phase 2

A Study of LY4515100 in Participants With Pain Following Third Molar Removal

Acute PainMolar, ThirdMolar+1 more
Eli Lilly and Company212 enrolled1 locationNCT07511816
Recruiting

Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain

Activity LevelMusculoskeletal Pain - Acute and Subacute ConditionsExercise (EX)+1 more
Istinye University55 enrolled1 locationNCT07528807
Recruiting
Not Applicable

Dry Needlig Vesus Tecartherapy in Low-back Pain Treatment

Low Back Pain
University of Alcala60 enrolled1 locationNCT05422040