RecruitingNCT05763277

Ate-Bev Early Response Prediction Model in Advanced HCC

Developing Atezolizumab-Bevacizumab Treatment Response Early Prediction Model in Advanced Hepatocellular Carcinoma Patients


Sponsor

Seoul National University Hospital

Enrollment

170 participants

Start Date

Jul 22, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The prognosis of hepatocellular carcinoma is poor compared to other carcinomas. Many drugs have recently been developed, and recently, atezolizumab-bevacizumab treatment was superior to sorafenib, the conventional treatment for advanced hepatocellular carcinoma. However, there is no information on the evaluation on the evaluation of treatment response for atezolizumab-bevacizumab combination therapy compared to atezolizumab alone or bevacizumab alone. Therefore, this study aimed to create a predictive model that can detect treatment response at an early stage.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study aims to develop a model that can predict early on — using imaging scans — whether a patient with advanced liver cancer (hepatocellular carcinoma, or HCC) is responding to a standard drug combination called atezolizumab plus bevacizumab. An early response prediction tool could help doctors make faster treatment decisions. **You may be eligible if...** - You have been diagnosed with advanced liver cancer (hepatocellular carcinoma) - You are scheduled to receive atezolizumab plus bevacizumab as your first treatment - You are willing to participate and have consented **You may NOT be eligible if...** - You have a history of severe allergy to contrast dye used in imaging - You have severe organ problems that meet certain exclusion criteria per clinical guidelines Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTEarly response evaluation

Atezolizumab and bevacizumab are administered every three weeks, and before to the second treatment cycle, blood tests and imaging tests are conducted (week 5). This precedes the standard response evaluation (week 9-12).


Locations(1)

Seoul National University Hospital

Seoul, South Korea

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05763277


Related Trials