RecruitingPhase 2NCT05765877

Neoadjuvant WX-0593 in Resectable ALK-positive or ROS1-positive Non-small Cell Lung Cancer

Neoadjuvant WX-0593 in Resectable ALK-positive or ROS1-positive Non-small Cell Lung Cancer : a Single-arm, Exploratory Trial


Sponsor

Pingping Song

Enrollment

26 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, exploratory trial to evaluate the efficacy and safety of neoadjuvant WX-0593 in patients with resectable ALK-positive or ROS1- positive non-small cell lung cancer(NSCLC).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a drug called WX-0593 given before surgery in patients with non-small cell lung cancer (NSCLC) that carries specific gene changes (ALK or ROS1 mutations). The goal is to shrink the tumor before it is surgically removed. **You may be eligible if...** - You have been diagnosed with NSCLC confirmed by biopsy - Your tumor tests positive for ALK or ROS1 gene mutations - Your cancer is at stage IB through IIIA - Surgery to remove the cancer is considered possible by your medical team - You are in good overall health (ECOG 0–1) - You have at least one measurable tumor **You may NOT be eligible if...** - You have received prior systemic treatment for your lung cancer - Your cancer is at a more advanced stage - You have inadequate organ function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGWX-0593 Tablets

60 mg of WX-0593 tablets, once daily for 7 days, followed by 180 mg of WX-0593 tablets, once daily in a 28-days cycle.


Locations(1)

Shandong Cancer Hospital and Institute

Jinan, Shandong, China

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NCT05765877


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