RecruitingNCT05767242

Early Neurophysiological Markers of Language Impairments

Early Neurophysiological Markers of Language Impairments: a Longitudinal Study on Infants At Familial Risk

Sponsor

IRCCS Eugenio Medea

Enrollment

100 participants

Start Date

Feb 21, 2022

Study Type

OBSERVATIONAL

Conditions

Development, Infant Learning Disabilities Developmental Language Disorder Development, Language

Summary

The present project aims at identifying very early electrophysiological risk markers for language impairments. The long-term goals of the study include the characterization of learning developmental trajectories in children at high risk for language impairments. In this project, all the infants of the Medea BabyLab cohort are followed-up until school age. Since these infants have complete information on early electrophysiological markers, the final goal of the project is the characterization of their learning developmental trajectories and the construction of a multi-factor prognostic model that includes the neurophysiological processes underlying basic-level skills as potential biomarkers for predicting later reading and spelling skills.

Eligibility

Min Age: 6 MonthsMax Age: 8 Years

Inclusion Criteria3

Healthy infants aged \<24 months
Infants with and without familial risk for language impairments (infants are assigned to the group with familial risk if at least one first-degree relative had a certified (clinical) diagnosis of language impairment or learning disability
Both parents are native-Italian speakers

Exclusion Criteria4

Gestational age \< 37 weeks and/or birth weight \< 2500 grams
APGAR scores at birth at 1' and 5' \< 7
Bayley Cognitive Score \< 7
Presence of certified diagnosis of intellectual deficiency, attention-deficit disorder, sensorial and neurological disorders, or autism within first-degree relative

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