Postoperative Adjuvant Therapy for Non-clear Renal Cell Carcinoma With High-risk Recurrence Factors

This study is testing adjuvant (post-surgery) treatment options for patients with certain rare types of kidney cancer — non-clear cell renal cell carcinoma — that carry a high risk of coming back after surgery. **You may be eligible if...** - You are between 18 and 75 years old - You have had surgery for a confirmed non-clear cell renal cell carcinoma (specifically papillary RCC, collecting duct carcinoma, SMARCB1-deficient renal medullary carcinoma, or FH-deficient RCC, among others) - Your cancer has certain high-risk features based on pathology results (stage, grade, or specific subtype) - Your cancer has not spread to distant organs (M0) **You may NOT be eligible if...** - You have clear cell, chromophobe, or eosinophilic RCC - Your cancer has spread beyond the kidney to distant organs - You do not have adequate organ function Talk to your doctor to see if this trial is right for you.