RecruitingNCT05771922

Implication of New High Resolution Ultrasonographic Modalities for Diagnosis of Fetal Nervous System Anomalies

Role of New High Resolution Ultrasonographic Modalities for Diagnosis of Fetal Nervous System Anomalies


Sponsor

Woman's Health University Hospital, Egypt

Enrollment

150 participants

Start Date

Nov 30, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The fetal CNS screening examination during the mid-trimester scan in low-risk pregnancies should include evaluation of the fetal head and spine, using transabdominal sonography. Evaluation of two axial planes allows visualization of the relevant cerebral structures to assess the anatomic integrity of the fetal brain.These planes are commonly referred to as the transventricular and transcerebellar planes. A third plane, the so-called transthalamic plane, is frequently added, mostly for the purpose of biometry. Structures that should be noted in the routine examination include the lateral ventricles, the cerebellum, the cisterna magna, and the cavum septi pellucidi (CSP). Head shape and brain texture should also be noted on these views.


Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 28 Years

Inclusion Criteria1

  • Suspicion of CNS or spinal malformation at routine screening ultrasound Suspicion of CNS or spinal malformation at nuchal translucency scan Family history of inheritable CNS spinal malformations Previous pregnancy complicated by fetal brain or spinal malformation Fetus with congenital heart disease Monochorionic twins Suspected congenital intrauterine infection Exposure to teratogens known to affect neurogenesis

Exclusion Criteria1

  • Low risk pregnancy

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Interventions

DIAGNOSTIC_TESTHigh-resolution ultrasonography

High-resolution ultrasonography to detect fetal CNS anomalies


Locations(1)

Woman's Health University Hospital

Asyut, Egypt

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NCT05771922