High- Versus Low-calcium Water for Bone Health
Metabolic Response to the Consumption of Waters With Different Calcium Content: a Cross-over Clinical Study
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
41 participants
Mar 2, 2023
INTERVENTIONAL
Conditions
Summary
The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water first and high-calcium water afterward.
Eligibility
Inclusion Criteria3
- Body mass index ≥ 18 and \< 30
- Maintenance of diet and physical activity lifestyle throughout the duration of the study
- Acceptance of informed consent
Exclusion Criteria7
- Consumption of water with calcium \> 150 mg/L
- Pregnancy (as established by self-declaration), breastfeeding, menopause
- Inability to follow the study protocol
- Cardiac, vascular, renal, and oncological disease
- Neuropsychiatric disease, developmental disorders
- Disease or past surgery affecting the gastrointestinal tract
- Drugs that interfere with bone (e.g. corticosteroids) or with fluid balance (e.g. diuretics)
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Interventions
All cohort subjects are asked to consume water with less than 5 mg/L of calcium first, then are asked to consume water with at least 400 mg/L of calcium
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05772364