RecruitingNCT05773638

Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West

Sponsor

University Hospital, Brest

Enrollment

100 participants

Start Date

Dec 26, 2021

Study Type

OBSERVATIONAL

Conditions

Von Willebrand Diseases

Summary

Due to increasing of life expectancy, patients with von Willebrand disease are exposed to age-related pathologies such as cancer or cardiovascular diseases. Management of thrombotic events is challenging given the inherent bleeding risk in von Willebrand disease. Few data are currently available in the literature. The aim of the study is to describe the frequency and nature of arterial and venous thromboembolic events and atrial fibrillation in patients with von Willebrand disease in the West of France. The investigators will perform a retrospective multicenter study conducted in the von Willebrand population of the French West. Von Willebrand adult patients followed in one of the French West medical centers participating in the study, who presented deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia, atrial fibrillation, arteriopathy of the lower limbs, angina will be eligible.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at cardiovascular and blood clot-related events (such as deep vein thrombosis, stroke, or heart attack) in adults with Von Willebrand disease (VWD) — a genetic bleeding disorder — who have experienced these events. Researchers want to understand how often these complications occur and what factors contribute to them in this unique patient population. **You may be eligible if...** - You are an adult with Von Willebrand disease - You are followed at a reference center in western France - You have experienced a cardiovascular or blood clot event (such as a stroke, heart attack, deep vein thrombosis, or pulmonary embolism) - You have consented (or not objected) to being included in the BERHLINGO database **You may NOT be eligible if...** - You have objected to inclusion in the database - Your VWD is acquired (not genetic) Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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